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Approximately one-third of patients lost more than 20% of body weight at 68 weeks of the STEP 2 trial, so it really is a breakthrough drug. Semaglutide at a Glance Level of Concern Should ophthalmologists be concerned about an uptick of DR progression in a new cohort of patients

FDA's concerns include potential immunogenicity for certain administration routes, peptide-related impurities, and the fact that Ipamorelin acetate contains unnatural amino acids that add characterization complexity

Technique and aftercare A new needle must be used each time to avoid dull tips, contamination, or blocked flow

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